Plasminogen Deficiency

Laboratory Evaluation

In patients with lesions suspected to be ligneous, a plasminogen antigen and activity level should be obtained. As the majority of clinical lesions have been associated with type I deficiency, it is important to evaluate both assays to demonstrate a decreased plasminogen activity with concordant decrease in protein level. Plasminogen activity is measured using a chromogenic assay with typical normal range of 70-130%; while antigenic testing is commonly performed via immunologic assays with a reported normal range of 6-25 mg/dL.1 By the age of 1 year, plasminogen levels stabilize and do not subsequently vary with age.47