Prothrombin (Factor II) Deficiency


Several international organizations have mechanisms and databases for data collection that offer general information on the various RBDs, provide epidemiologic information on RBDs, or establish committees of international experts to help define standardized guidelines for the management of individuals with RBDs. These ongoing efforts include the International Rare Bleeding Disorders Database project (, the World Federation of Hemophilia (WFH,, and International Society on Thrombosis and Haemostasis (ISTH) Factor VIII, Factor IX and Rare Coagulation Disorders Scientific and Standardization Committee (SSC). Initiatives such as the ThromboGenomics project through the ISTH SSC aim to develop a comprehensive genetic database based on next-generation sequencing to help streamline the diagnosis of patients with rare bleeding and platelet disorders.45 These organizations and their services are summarized in the table below.