Factor XI Deficiency


Several possible treatments are available for FXI deficiency.37 The pros and cons of each are shown in Table 1, and the treatment of specific clinical scenarios is considered in Table 2. These tables do not take into account the more recent research with thrombin generation tests (TGT), instead they base treatment choices on FXI:C levels and bleeding history. At the present time however, the TGT is not readily available.

Click on table to enlarge.

The first issue is to decide whether treatment is required. This decision will depend on the hemostatic challenge under consideration, the patient’s past medical history with interventions, if present, and to some extent on the level of deficiency.32 Many women with severe FXI deficiency have given birth without treatment aimed at increasing the FXI level; they would not be eligible for spinal anaesthesia in these circumstances.